- Furthering the understanding of how platelets are activated
- Outreach for the British Heart Foundation (BHF volunteers day)
Craig Hughes
-
+44 (0) 118 378 8169
-
Associate Professor
Areas of interest
- Understanding signal transduction in platelets, and how this contributes to platelet activation, thrombosis and haemostasis
- Identifying novel kinase substrates
- Discovery of the fish collagen receptor (G6f-like)
Research centres and groups
National Collaborators
- Prof. Steve Watson - University of Birmingham
- Dr. Mike Tomlinson - University of Birmingham
- Dr. Chris O'Callaghan - University of Oxford
- Dr. Cédric Ghevaert - University of Cambridge
International Collaborators
- Prof. Wilfried Ellmeier - Medical University of Vienna
Awards and honours
Esteem Factors
- Peer reviewer for Journal of Thrombosis and Haemostasis, Thrombosis Research, Platelets, and Scientific Reports
Selected publications
- Book chapter: 'GPVI and CLEC-2'. In 'Platelets, 3rd Edition' (Michelson AD, ed), Academic Press/Elsevier Science (2013)
Impact, enterprise and outreach
Publications
-
Soriano Jerez, E.
,
Gibbins, J.
ORCID: 0000-0002-0372-5352
,
Hughes, C.
ORCID: 0000-0002-9790-5820
(2021)
Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B.
Platelets
, 32
(6).
pp.
761-769.
ISSN:
0953-7104
|
doi:
https://dx.doi.org/10.1080/09537104.2021.1882668
-
Gaspar, R.
,
Unsworth, A.
,
Al-Dibouni, A.
,
Bye, A.
,
Sage, T.
,
Stewart, M.
,
Cox, R.
,
Gibbins, J.
ORCID: 0000-0002-0372-5352
,
Sellayah, D.
,
Hughes, C.
ORCID: 0000-0002-9790-5820
(2021)
Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.
Scientific Reports
, 11
ISSN:
2045-2322
|
doi:
https://dx.doi.org/10.1038/s41598-020-80373-3
- Nicolson, P. , Nock, S. , Hinds, J. , Garcia-Quintanilla, L. , Smith, C. , Campos, J. , Brill, A. , Pike, J. , Khan, A. , Poulter, N. , Kavanagh, D. , Watson, S. , Watson, C. , Clifford, H. , Huissoon, A. , Pollitt, A. , Eble, J. , Pratt, G. , Watson, S. , Hughes, C. (2020) Low dose Btk inhibitors selectively block platelet activation by CLEC-2. Haematologica , 105 (1). ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2019.218545
- Nicolson, P. , Hughes, C. , Watson, S. , Nock, S. , Hardy, A. , Watson, C. , Montague, S. , Clifford, H. , Huissoon, A. , Malcor, J. , Thomas, M. , Pollitt, A. , Tomlinson, M. , Pratt, G. , Watson, S. (2018) Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI. Haematologica , 103 (12). pp. 2097-2108. ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2018.193391
- Hughes, C. (2018) How to perform aggregometry and lumi-aggregometry in mouse platelets. Platelets , 29 (7). pp. 638-643. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2018.1478074
- Mangin, P. , Onselaer, M. , Receveur, N. , Le Lay, N. , Hardy, A. , Wilson, C. , Sanchez, X. , Loyau, S. , Dupuis, A. , Babar, A. , Miller, J. , Philippou, H. , Hughes, C. , Herr, A. , Ariens, R. , Mezzano, D. , Jandrot-Perrus, M. , Gachet, C. , Watson, S. (2018) Immobilized fibrinogen activates human platelets through GPVI. Hematologica , 103 (5). pp. 898-907. ISSN: 1592-8721 | doi: https://dx.doi.org/10.3324/haematol.2017.182972
- Lombard, S. , Pollitt, A. , Hughes, C. , Di, Y. , Mckinnon, T. , O'Callaghan, C. , Watson, S. (2018) Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis. Platelets , 29 (7). pp. 716-722. ISSN: 0953-7104 | doi: https://dx.doi.org/10.1080/09537104.2017.1356919
- Bye, A. , Unsworth, A. , Desborough, M. , Hildyard, C. , Appleby, N. , Bruce, D. , Kriek, N. , Nock, S. , Sage, T. , Hughes, C. , Gibbins, J. (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances , 1 (26). pp. 2610-2623. ISSN: 2473-9529 | doi: https://dx.doi.org/10.1182/bloodadvances.2017011999
- Cherpokova, D. , Bender, M. , Morowski, M. , Kraft, P. , Schuhmann, M. , Akbar, S. , Sultan, C. , Hughes, C. , Kleinschnitz, C. , Stoll, G. , Dragone, L. , Watson, S. , Tomlinson, M. , Nieswandt, B. (2015) SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Blood , 125 (1). pp. 185-194. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2014-06-580597
- Hughes, C. , Finney, B. , Koentgen, F. , Lowe, K. , Watson, S. (2015) The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets. Blood , 125 (1). pp. 144-154. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2014-05-579375
- Alshehri, O. , Montague, S. , Watson, S. , Carter, P. , Sarker, N. , Manne, B. , Miller, J. , Herr, A. , Pollitt, A. , O'Callaghan, C. , Kunapuli, S. , Arman, M. , Hughes, C. , Watson, S. (2015) Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands. Biochemical Journal , 468 (3). pp. 459-473. ISSN: 0264-6021 | doi: https://dx.doi.org/10.1042/BJ20150192
- Alshehri, O. , Hughes, C. , Montague, S. , Watson, S. , Frampton, J. , Bender, M. , Watson, S. (2015) Fibrin activates GPVI in human and mouse platelets. Blood , 126 (13). pp. 1601-1608. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2015-04-641654
- Dütting, S. , Vögtle, T. , Morowski, M. , Schiessl, S. , Schäfer, C. , Watson, S. , Hughes, C. , Ackermann, J. , Radtke, D. , Hermanns, H. , Watson, S. , Nitschke, L. , Nieswandt, B. (2014) Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. Circulation Research , 114 (3). pp. 444-453. ISSN: 0009-7330 | doi: https://dx.doi.org/10.1161/CIRCRESAHA.114.302670
- Pollitt, A. , Poulter, N. , Gitz, E. , Navarro-Nuñez, L. , Wang, Y. , Hughes, C. , Thomas, S. , Nieswandt, B. , Douglas, M. , Owen, D. , Jackson, D. , Dustin, M. , Watson, S. (2014) Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. The Journal of Biological Chemistry , 289 (52). pp. 35695-35710. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M114.584284
- Yu, T. , Finney, B. , Hughes, C. , Dehghani, H. , Claridge, E. , Thomas, S. (2013) Three dimensional analysis of cardiovascular development in mouse embryos using X-ray microcomputed tomography.
- Pollitt, A. , Hughes, C. , Watson, S. (2013) GPVI and CLEC-2. In: Michelson, A. , (eds.) Platelets. 3rd edition. Academic Press , Amsterdam. pp. 215-231. ISBN: 9780123878373 | doi: https://dx.doi.org/10.1016/B978-0-12-387837-3.00011-0
- Hughes, C. , Sinha, U. , Pandey, A. , Eble, J. , O'Callaghan, C. , Watson, S. (2013) Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). The Journal of Biological Chemistry , 288 (7). pp. 5127-5135. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M112.411462
- Manne, B. , Getz, T. , Hughes, C. , Alshehri, O. , Dangelmaier, C. , Naik, U. , Watson, S. , Kunapuli, S. (2013) Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2). The Journal of Biological Chemistry , 288 (11). pp. 7717-7726. ISSN: 1083-351X | doi: https://dx.doi.org/10.1074/jbc.M112.424473
- Jarvis, G. , Bihan, D. , Hamaia, S. , Pugh, N. , Ghevaert, C. , Pearce, A. , Hughes, C. , Watson, S. , Ware, J. , Rudd, C. , Farndale, R. (2012) A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1). Journal of Thrombosis and Haemostasis , 10 (2). pp. 268-277. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2011.04567.x
- Finney, B. , Schweighoffer, E. , Navarro-Núñez, L. , Bénézech, C. , Barone, F. , Hughes, C. , Langan, S. , Lowe, K. , Pollitt, A. , Mourao-Sa, D. , Sheardown, S. , Nash, G. , Smithers, N. , Reis e Sousa, C. , Tybulewicz, V. , Watson, S. (2012) CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood , 119 (7). pp. 1747-1756. ISSN: 0006-4971 | doi: https://dx.doi.org/10.1182/blood-2011-09-380709
- Hughes, C. , Radhakrishnan, U. , Lordkipanidzé, M. , Egginton, S. , Dijkstra, J. , Jagadeeswaran, P. , Watson, S. (2012) G6f-like is an ITAM-containing collagen receptor in thrombocytes. PLoS ONE , 7 (12). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0052622
- Brazón, J. , Hughes, C. , Mori, J. , Sevcik, C. , D'suze, G. , Watson, S. (2011) Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway. Platelets , 22 (3). pp. 165-172. ISSN: 0953-7104 | doi: https://dx.doi.org/10.3109/09537104.2010.544343
- Hughes, C. (2010) Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins.
- Hughes, C. , Pollitt, A. , Mori, J. , Eble, J. , Tomlinson, M. , Hartwig, J. , O'Callaghan, C. , Fütterer, K. , Watson, S. (2010) CLEC-2 activates Syk through dimerization. Blood , 115 (14). pp. 2947-2955. ISSN: 1528-0020 | doi: https://dx.doi.org/10.1182/blood-2009-08-237834
- Hughes, C. , Navarro-Núñez, L. , Finney, B. , Mourão-Sá, D. , Pollitt, A. , Watson, S. (2010) CLEC-2 is not required for platelet aggregation at arteriolar shear. Journal of Thrombosis and Haemostasis , 8 (10). pp. 2328-2332. ISSN: 1538-7933 | doi: https://dx.doi.org/10.1111/j.1538-7836.2010.04006.x
- Grygielska, B. , Hughes, C. , Watson, S. (2009) Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide.. Journal of thrombosis and haemostasis : JTH , 7 (2). pp. 339-46. ISSN: 1538-7836
- Spalton, J. , Mori, J. , Pollitt, A. , Hughes, C. , Eble, J. , Watson, S. (2009) The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.. Journal of thrombosis and haemostasis : JTH , 7 (7). pp. 1192-9. ISSN: 1538-7836
- Riba, R. , Hughes, C. , Graham, A. , Watson, S. , Naseem, K. (2008) Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.. Journal of thrombosis and haemostasis : JTH , 6 (6). pp. 1012-20. ISSN: 1538-7836
- Hughes, C. , Auger, J. , McGlade, J. , Eble, J. , Pearce, A. , Watson, S. (2008) Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.. Journal of thrombosis and haemostasis : JTH , 6 (12). pp. 2152-9. ISSN: 1538-7836
- Pears, C. , Thornber, K. , Auger, J. , Hughes, C. , Grygielska, B. , Protty, M. , Pearce, A. , Watson, S. (2008) Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets. PLoS ONE , 3 (11). ISSN: 1932-6203 | doi: https://dx.doi.org/10.1371/journal.pone.0003793
- Suzuki-Inoue, K. , Hughes, C. , Inoue, O. , Kaneko, M. , Cuyun-Lira, O. , Takafuta, T. , Watson, S. , Ozaki, Y. (2007) Involvement of Src kinases and PLCgamma2 in clot retraction.. Thrombosis research , 120 (2). pp. 251-8. ISSN: 0049-3848
- Hughan, S. , Hughes, C. , McCarty, O. , Schweighoffer, E. , Soultanova, I. , Ware, J. , Tybulewicz, V. , Watson, S. (2007) GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.. Arteriosclerosis, thrombosis, and vascular biology , 27 (2). pp. 422-9. ISSN: 1524-4636
- Dhanjal, T. , Ross, E. , Auger, J. , McCarty, O. , Hughes, C. , Senis, Y. , Buckley, C. , Watson, S. (2007) Minimal regulation of platelet activity by PECAM-1.. Platelets , 18 (1). pp. 56-67. ISSN: 0953-7104
- García, A. , Senis, Y. , Antrobus, R. , Hughes, C. , Dwek, R. , Watson, S. , Zitzmann, N. (2006) A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.. Proteomics , 6 (19). pp. 5332-43. ISSN: 1615-9853