- Frontiers loop:https://loop.frontiersin.org/people/456082/overview
- Research gate: https://www.researchgate.net/scientific-contributions/Viridiana-Alcantara-Alonso-2080192477
- ORCID iD: 0000-0002-9782-2398
Viridiana Alcantara-Alonso
Areas of interest
- Atherosclerosis
- Cardiovascular disease
- Metabolism
- Neuroendocrinology
Expertise
- Western-Blotting
- ELISA
- Real-time qPCR
- Confocal microscopy
Background
As part of my master’s and PhD studies at the Universidad Nacional Autonoma de Mexico, I investigated some of the molecular mechanisms involved in stress responses and metabolism. Currently, I am exploring the effects of a potential treatment for atherosclerosis using in vitro methods. I am analysing the intracellular pathways implicated in the formation of the atherosclerotic lesion and the possibility of regression with cysteamine and cysteamine-related molecules. The effectiveness of these treatments is crucial for the management of cardiovascular disease, one of the main causes of death and disability worldwide.
Selected publications
- Alvarez-Salas E, Alcántara-Alonso V, Matamoros-Trejo G, Vargas MA, Morales-Mulia M, de Gortari P. Mediobasal hypothalamic and adenohypophyseal TRH-degrading enzyme (PPII) is down-regulated by zinc deficiency. International Journal of Developmental Neuroscience 2015,46:115-124. DOI: 10.1016/j.ijdevneu.2015.08.001
- Puga L, Alcántara-Alonso V, Coffeen U, Jaimes O, de Gortari P. TRH injected into the nucleus accumbens shell releases dopamine and reduces feeding motivation in rats.Behav Brain Res 2016, 306:128-136. DOI: 10.1016/j.bbr.2016.03.031
- Valdés-Moreno MI, Alcántara-Alonso V, Estrada-Camarena E, Mengod G, Amaya MI, Matamoros-Trejo G, de Gortari P. Phosphodiesterase-7 inhibition affects accumbal and hypothalamic thyrotropin-releasing hormone expression, feeding and anxiety behavior of rats. Behav Brain Res. 2017 Feb 15;319:165-173. DOI: 10.1016/j.bbr.2016.11.027
- Alcántara-Alonso V, Amaya MI, Matamoros-Trejo G, de Gortari P. Altered functionality of the corticotrophin-releasing hormone receptor-2 in the hypothalamic paraventricular nucleus of hyperphagic maternally separated rats.Neuropeptides. 2017 Jun; 63:75-82. DOI: 10.1016/j.npep.2017.01.006
- Alcántara-Alonso V, Panetta P, de Gortari P, Grammatopoulos DK. Corticotropin-Releasing Hormone As the Homeostatic Rheostat of Feto-Maternal Symbiosis and Developmental ProgrammingIn Uteroand Neonatal Life.Front Endocrinol (Lausanne). 2017 Jul 11;8:161. DOI: 10.3389/fendo.2017.00161
- Alcántara-Alonso V, Alvarez-Salas E, Matamoros-Trejo G, de Gortari P. Intrauterine Zn Deficiency Favors Thyrotropin-Releasing Hormone-Increasing Effects on Thyrotropin Serum Levels and Induces Subclinical Hypothyroidism in Weaned Rats. Nutrients. 2017 Oct 18;9:1139. DOI: 10.3390/nu9101139
- de Gortari P., Alcántara-Alonso V., Matamoros-Trejo G., Amaya M.I.,Alvarez-Salas E. Differential effects of leptin administration on feeding and HPT axis function in early-life overfed adult rats. Peptides. 2020 Feb 24;127:170285. DOI: 10.1016/j.peptides.2020.170285
- Meijles DN, Cull JJ, Cooper STE, Markou T, Hardyman MA, Fuller SJ, Alharbi HO, Haines ZHR, Alcántara-Alonso V, Glennon PE, Sheppard MN, Sugden PH, Clerk A. The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension. Clin Sci (Lond). 2021 Jul 30;135(14):1631-1647. DOI: 10.1042/CS20210192
- Alcántara-Alonso E, Molinar-Ramos F, González-López JA, Alcántara-Alonso V, Muñoz-Pérez MA, Lozano-Nuevo JJ, Benítez-Maldonado DR, Mendoza-Portillo E. High triglyceride to HDL-cholesterol ratio as a biochemical marker of severe outcomes in COVID-19 patients. Clin Nutr ESPEN. 2021 Aug;44:437-444.DOI: 10.1016/j.clnesp.2021.04.020
- Chávez J, Alcántara-Alonso V, García-Luna C, Soberanes-Chávez P, Grammatopoulos D, de Gortari P.Hypothalamic TRH mediates anorectic effects of serotonin in rats. eNeuro. 2022 May 11;9(3):ENEURO.0077-22.2022. DOI: 10.1523/ENEURO.0077-22.2022
Connections